Neuropathic pain can occur in systemic disease or toxic states causing purely sensory or sensorimotor peripheral neuropathy and after peripheral nerve injury. Precise estimates of the prevalence of neuropathic pain are not available; there are many patients with painful diabetic neuropathy, postherpetic neuralgia and direct nerve injury suffered from chronic neuropathic pain. Especially neuropathic pain is very difficult to treat and basic pathomachnism is also quite complex. Recently pregabalin structurally related to gabapentin is developed and usable in clinics. Similarly to gabapentin, which is effective in the treatment of neuropathic pain, pregabalin specifically targets an important pronociceptive site of the central sensitization cascade.

KeywordsNeuropathic pain, Pregabalin, Gabapentin, Painful Diabetic Neuropathy, Postherpetic Neuralgia